Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown
adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on …

c-Jun N-terminal kinase (JNK), or stress-activated protein kinase, is an important member of
the mitogen-activated protein kinase superfamily, the members of which are readily …

Cells are constantly generating reactive oxygen species (ROS) during aerobic metabolism.
As a consequence, each cell is equipped with an extensive antioxidant defence system to …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

The liver is a crucial metabolic organ that has a key role in maintaining immune and
endocrine homeostasis. Accumulating evidence suggests that chronic liver disease might …

La céramide, un nouveau second messager et lipide bioactif, est principalement formée lors
de l'hydrolyse de la sphingomyéline par des sphingomyélinases. Au moins deux …

Tumor necrosis factor (TNF) is being utilized as an antineoplastic agent for the treatment of
patients with locally advanced solid tumors. However, its role in cancer therapy is debated …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …