The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

In water environment, the interaction between environmental pollutants is very complex,
among which pesticides and antibiotics are dominant. However, most studies only focus on …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-
cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year …

Cancer is a multifaceted disease comprising a combination of genetic, metabolic and
signalling aberrations, which severely disrupt the normal homeostasis of cell growth and …

Hepatocellular carcinoma, one of the most common solid tumors worldwide, is poorly
responsive to available chemotherapeutic approaches. While systemic chemotherapy is of …