Developing recombinant protein pharmaceuticals has proved to be very challenging
because of both the complexity of protein production and purification, and the limited …

▪ Abstract Numerous organisms are capable of surviving more or less complete dehydration.
A common feature in their biochemistry is that they accumulate large amounts of …

Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms
that can withstand extended periods of inanimation. Since this discovery, the properties of …

This paper contains a review of the history, natural occurrence, human consumption,
metabolism, manufacture, and the results of eight standardized animal safety studies using …

Simple sugars, especially disaccharides, stabilize biomaterials of various composition
during air-drying or freeze-drying. We and others have provided evidence that direct …

The osmoadaptation of most micro-organisms involves the accumulation of K+ ions and one
or more of a restricted range of low molecular mass organic solutes, collectively termed …

Trehalose, a sugar produced by a wide variety of organisms, has long been known for its
role in protecting certain organisms from desiccation. Recent work in yeast indicates that …

Trehalose (α-d-glucopyranosyl α-d-glucopyranoside) is a unique sugar capable of
protecting biomolecules against environmental stress. It is a stable, colorless, odor-free and …

Publisher Summary This chapter focuses on “food polymer science” approach and illustrates
various recent examples of the way it has been used to define structure–function …

We show that extremely fragile biomolecules such as DNA restriction and modifying
enzymes can be dried in vitro in the presence of trehalose with no loss of activity, even after …