Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

The rapid emergence of SARS-CoV-2 variants with multi-sites mutations is considered as a
major obstacle for the development of drugs and vaccines. Although most of the functional …

The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …

There remain great unmet needs to treat coronavirus infections in clinic, and the
development of novel antiviral agents is highly demanded. In this work, a phenotypic …

Aprotinin (APR) was discovered in 1930. APR is an effective pan-protease inhibitor, a typical
“magic shotgun”. Until 2007, APR was widely used as an antithrombotic and anti …

Since the appearance of SARS-CoV-2 in 2019, the ensuing COVID-19 (Corona Virus
Disease 2019) pandemic has posed a significant threat to the global public health system …

Abstract Coronavirus disease 2019 (COVID-19) still remains the most disastrous infection
continuously affecting millions of people worldwide. Herein, we performed a comparative …

A computer-aided drug design of new derivatives of nirmatrelvir, an orally active inhibitor of
the main-protease (Mpro) of the severe acute respiratory syndrome Coronavirus 2 (SARS …

The COVID-19 pandemic was caused by the SARS-CoV-2 virus, frequent mutations
occurred to the wild-type virus resulting in evolved new variants. The WHO classified the …