Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-
amorphous systems, are a result of the combination of an active pharmaceutical ingredient …

Drug–drug cocrystals, which can regulate physicochemical properties of individual drugs
and might produce synergistic therapeutic effects, have drawn growing interest in the …

Psoriasis is a chronic inflammatory disease occurring due to a large cascade of molecular
and biological processes. Pentoxifylline (PTX) has a profound anti-inflammatory activity and …

Machine learning was employed on the experimental crystal structures of the Cambridge
Structural Database (CSD) to derive an intermolecular force field for all available types of …

This study explores the preparation and investigation of dissolution properties of piroxicam
cocrystals. Differential scanning calorimetry (DSC) was used to determine the capability of …

Two-component crystals such as pharmaceutical cocrystals and salts have been proven as
an effective strategy to improve physicochemical and biopharmaceutical properties of drugs …

Abstract Cocrystallization of 2-aminothiazole/2-aminobenzothiazole with a set of organic
acids got a total of ten crystalline salts. The ten salts have been examined by XRD, IR and …

Novel crystalline forms of febuxostat (HFEB) salts were synthesized by liquid-assisted
cogrinding with 2-methylimidazole (2MI) and di-2-pyridylamine (DPA) and characterized by …