Nanoparticle science is rapidly changing the landscape of various scientific fields and
defining new technological platforms. This is perhaps even more evident in the field of …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Intracellular bacterial pathogens gain entry to mammalian cells inside a vacuole derived
from the host membrane. Some of them escape the bacteria-containing vacuole (BCV) and …

Macropinocytosis is a widely-observed and evolutionarily-conserved endocytic process
found in the eukaryotic cells. In comparison to other endocytic routes, macropinocytosis …

Introduction Adequate transfection efficiency is indispensable to safe and effective delivery
of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a …

The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host
cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we …

Salmonella enterica induces membrane ruffling and genesis of macropinosomes during its
interactions with epithelial cells. This is achieved through the type three secretion system‐1 …

Highlights•Electron cryotomography is a powerful in situ imaging technique but restricted to
thin samples.•Cryo-focused ion beam milling allows for sample thinning prior to …

A variety of seemingly non-specific symptoms manifest within the gastrointestinal (GI) tract,
particularly in the colon, in response to inflammation, infection, or a combination thereof …

Nanosized materials have been proposed for a wide range of biomedical applications, given
their unique characteristics. However, how these nanomaterials interact with cells and …