The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …

Chimeric antigen receptor (CAR) T cells have not induced meaningful clinical responses in
solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during …

Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for
enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq …

Highly coordinated changes in gene expression underlie T cell activation and exhaustion.
However, the mechanisms by which such programs are regulated and how these may be …

Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on
systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer's …

The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …

Currently, immunotherapy targeting programmed cell death 1 (PD-1) or programmed death
ligand 1 (PD-L1) has revolutionized the treatment strategy of human cancer patients …

Bone is the most common site of breast cancer metastasis. Bone metastasis is incurable and
is associated with severe morbidity. Utilizing an immunocompetent mouse model of …