[HTML][HTML] Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
[HTML][HTML] Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
[HTML][HTML] Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
[HTML][HTML] A materials-science perspective on tackling COVID-19
The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in
providing tools and technologies for antiviral research and treatment development. In this …
providing tools and technologies for antiviral research and treatment development. In this …
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
[HTML][HTML] Challenges of organoid research
MG Andrews, AR Kriegstein - Annual review of neuroscience, 2022 - annualreviews.org
Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …
contain tissue resident cell types and reflect features of early tissue organization. Neural …
Progress and potential in organoid research
G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
A brief history of organoids
C Corrò, L Novellasdemunt… - American Journal of …, 2020 - journals.physiology.org
In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …
diseases. Although the conventional monolayer cell cultures have been widely used in the …