Mucocutaneous keratinocytes and bronchial epithelial cells express nicotinic acetylcholine
receptors (nAChRs). Emerging evidence indicates that nAChRs can be stimulated also by …

Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma (PPK) disease with
an estimated prevalence of 1: 100,000. Clinically, the onset of the disease is typically soon …

The majority of keratinization disorders are referred to as Mendelian disorders of
cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible …

Smoking is associated with increased risk and poorer prognosis of pancreatic ductal
adenocarcinoma (PDAC). Nicotine acts through cholinergic nicotinic receptors, preferentially …

Abstract Background Mal de Meleda (MDM) is a rare inherited autosomal recessive
genodermatosis characterized by palmoplantar keratoderma (PPK) with transgrediens and …

Summary Background Mal de Meleda (MDM) is palmoplantar erythrokeratoderma with an
autosomal recessive inheritance and is caused by a mutation in the gene encoding SLURP …

Identification of the biochemical pathways involved in the transformation from primary to
metastatic melanoma is an area under intense investigation. A 2DE proteomics approach …

Papillon-Lefèvre syndrome (PLS) is a rare autosomal-recessive genodermatosis
characterized by palmoplantar hyperkeratosis and severe early-onset periodontitis. The …

Recent research has demonstrated that mucocutaneous epithelial cells express functional
nicotinic acetylcholine receptors (nAChRs) and that tobacco-derived carcinogenic …

Mal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma. It is
characterized by erythema and hyperkeratosis of the palms and soles that progressively …