Descending pain modulation and chronification of pain

MH Ossipov, K Morimura, F Porreca - Current opinion in …, 2014 - journals.lww.com
Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …

[HTML][HTML] Central modulation of pain

MH Ossipov, GO Dussor… - The Journal of clinical …, 2010 - Am Soc Clin Investig
It has long been appreciated that the experience of pain is highly variable between
individuals. Pain results from activation of sensory receptors specialized to detect actual or …

The value of “multimodal” or “balanced analgesia” in postoperative pain treatment

H Kehlet, JB Dahl - Anesthesia & Analgesia, 1993 - journals.lww.com
Background Figure 1 shows the pathways of nociceptive stimuli, including those conducting
pain, from the site of surgical injury passing through the peripheral nervous system to the …

α2-Adrenergic Agonists for Regional Anesthesia: A Clinical Review of Clonidine (1984 - 1995)

JC Eisenach, M De Kock, W Klimscha - The Journal of the American …, 1996 - pubs.asahq.org
Alpha 2-ADRENERGIC mechanisms of analgesia have been exploited for more than 100 yr.
Cocaine, the first spinal anesthetic, produces analgesia primarily by its local anesthetic …

Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog

JC Murrell, LJ Hellebrekers - Veterinary anaesthesia and analgesia, 2005 - Elsevier
Abstract Alpha 2-adrenoreceptor agonists (α 2-agonists) are commonly used in small animal
anaesthesia for their potent sedative and analgesic properties, although concerns about …

Pharmacology of oral combination analgesics: rational therapy for pain

RB Raffa - Journal of clinical pharmacy and therapeutics, 2001 - Wiley Online Library
No single analgesic agent is perfect and no single analgesic can treat all types of pain. Yet
each agent has distinct advantages and disadvantages compared to the others. Hence …

Peripheral mechanisms of pain and analgesia

C Stein, JD Clark, U Oh, MR Vasko, GL Wilcox… - Brain research …, 2009 - Elsevier
This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine

R Aantaa, ML Jaakola, A Kallio… - The Journal of the …, 1997 - pubs.asahq.org
Background alpha 2-Adrenergic agonists have been shown to reduce anesthetic
requirements of other anesthetics, and they may even act as complete anesthetics by …

Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose

LK Cullen - British Veterinary Journal, 1996 - Elsevier
Medetomidine is a relatively new sedative analgesic in dogs and cats but some precautions
are required when using it. It is a potent α2-adrenoceptor agonist and stimulates receptors …

The perception and endogenous modulation of pain

MH Ossipov - Scientifica, 2012 - Wiley Online Library
Pain is often perceived an unpleasant experience that includes sensory and
emotional/motivational responses. Accordingly, pain serves as a powerful teaching signal …