Melatonin as an anti‐inflammatory agent modulating inflammasome activation

G Favero, L Franceschetti, F Bonomini… - International journal …, 2017 - Wiley Online Library
Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Melatonin signaling in T cells: Functions and applications

W Ren, G Liu, S Chen, J Yin, J Wang… - Journal of pineal …, 2017 - Wiley Online Library
Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

Melatonin: both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light

DX Tan, RJ Reiter, S Zimmerman, R Hardeland - Biology, 2023 - mdpi.com
Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Melatonin and sirtuins: a “not‐so unexpected” relationship

JC Mayo, RM Sainz… - Journal of pineal …, 2017 - Wiley Online Library
Epigenetic modifications, including methylation or acetylation as well as post‐transcriptional
modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in …

[HTML][HTML] The ROS/SIRT1/STAR axis as a target for melatonin ameliorating atrazine-induced mitochondrial dysfunction and steroid disorders in granulosa cells

XW Li, BJ Yi, ZY Wang, K Guo, MAU Saleem… - Ecotoxicology and …, 2024 - Elsevier
The granulosa cells (GCs) of birds are essential for the reproduction and maintenance of
populations in nature. Atrazine (ATR) is a potent endocrine disruptor that can interfere with …

Melatonin inhibits formation of mitochondrial permeability transition pores and improves oxidative phosphorylation of frozen-thawed ram sperm

Y Fang, C Zhao, H Xiang, X Zhao… - Frontiers in …, 2020 - frontiersin.org
Structural and functional damages to mitochondria of frozen-thawed sperm are a typical
cryoinjury, with mitochondrial permeability transition pore (MPTP) formation being the …

Local actions of melatonin in somatic cells of the testis

MB Frungieri, RS Calandra, SP Rossi - International journal of molecular …, 2017 - mdpi.com
The pineal hormone melatonin regulates testicular function through the hypothalamic-
adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis …

Melatonin transport into mitochondria

JC Mayo, RM Sainz, P González-Menéndez… - Cellular and molecular …, 2017 - Springer
Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic
unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the …

Melatonin protects against defects induced by deoxynivalenol during mouse oocyte maturation

M Lan, J Han, MH Pan, X Wan, ZN Pan… - Journal of Pineal …, 2018 - Wiley Online Library
Deoxynivalenol (DON) is one of the most prevalent fusarium mycotoxins in feedstuff and
food. DON causes detrimental effects on human and animal reproductive systems by …

Melatonin scavenger properties against oxidative and nitrosative stress: impact on gamete handling and in vitro embryo production in humans and other mammals

P Loren, R Sánchez, ME Arias, R Felmer… - International Journal of …, 2017 - mdpi.com
Oxidative and nitrosative stress are common problems when handling gametes in vitro. In
vitro development in mammalian embryos is highly affected by culture conditions, especially …