Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

V Schijns, A Fernández‐Tejada… - Immunological …, 2020 - Wiley Online Library
Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …

[HTML][HTML] Peptide-based supramolecular vaccine systems

CL O'Neill, PC Shrimali, ZE Clapacs, MA Files… - Acta biomaterialia, 2021 - Elsevier
Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

Protein supramolecular structures: from self-assembly to nanovaccine design

X Zottig, M Côté-Cyr, D Arpin, D Archambault… - Nanomaterials, 2020 - mdpi.com
Life-inspired protein supramolecular assemblies have recently attracted considerable
attention for the development of next-generation vaccines to fight against infectious …

Biologics to treat substance use disorders: Current status and new directions

M Pravetoni - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
Biologics (vaccines, monoclonal antibodies (mAb), and genetically modified enzymes) offer
a promising class of therapeutics to treat substance use disorders (SUD) involving abuse of …

Self-assembling peptide epitopes as novel platform for anticancer vaccination

M Rad-Malekshahi, MF Fransen… - Molecular …, 2017 - ACS Publications
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines
using novel nanocarriers based on self-assembling materials. Several studies demonstrated …

Current status and future prospects for the development of substance abuse vaccines

RD Heekin, D Shorter, TR Kosten - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Substance use disorders (SUD) are a significant threat to both individual and
public health. To date, SUD pharmacotherapy has focused primarily on agonist medications …

Engineering of a hybrid nanoparticle-based nicotine nanovaccine as a next-generation immunotherapeutic strategy against nicotine addiction: A focus on hapten …

Z Zhao, K Powers, Y Hu, M Raleigh, P Pentel, C Zhang - Biomaterials, 2017 - Elsevier
Although vaccination is a promising way to combat nicotine addiction, most traditional
hapten-protein conjugate nicotine vaccines only show limited efficacy due to their poor …

The effect of preexisting anti-carrier immunity on subsequent responses to CRM197 or Qb-VLP conjugate vaccines

MJ McCluskie, DM Evans, N Zhang… - …, 2016 - Taylor & Francis
Context: Certain antigens, such as haptens (small molecules), short peptides, and
carbohydrates (eg bacterial polysaccharides) are non-or poorly immunogenic unless …

Peptide-free synthetic nicotine vaccine candidates with α-galactosylceramide as adjuvant

XZ Chen, RY Zhang, XF Wang, XG Yin… - Molecular …, 2019 - ACS Publications
Peptides are generally needed as T-helper epitopes in nicotine vaccines to induce effective
antibody responses, but the highly polymorphic property of major histocompatibility complex …

Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models

LC Smith, O George - Neuropharmacology, 2020 - Elsevier
The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …