Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
V Schijns, A Fernández‐Tejada… - Immunological …, 2020 - Wiley Online Library
Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …
and non‐infectious conditions. Given that most chronic health conditions are thought to have …
[HTML][HTML] Peptide-based supramolecular vaccine systems
Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …
Protein supramolecular structures: from self-assembly to nanovaccine design
Life-inspired protein supramolecular assemblies have recently attracted considerable
attention for the development of next-generation vaccines to fight against infectious …
attention for the development of next-generation vaccines to fight against infectious …
Biologics to treat substance use disorders: Current status and new directions
M Pravetoni - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
Biologics (vaccines, monoclonal antibodies (mAb), and genetically modified enzymes) offer
a promising class of therapeutics to treat substance use disorders (SUD) involving abuse of …
a promising class of therapeutics to treat substance use disorders (SUD) involving abuse of …
Self-assembling peptide epitopes as novel platform for anticancer vaccination
M Rad-Malekshahi, MF Fransen… - Molecular …, 2017 - ACS Publications
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines
using novel nanocarriers based on self-assembling materials. Several studies demonstrated …
using novel nanocarriers based on self-assembling materials. Several studies demonstrated …
Current status and future prospects for the development of substance abuse vaccines
RD Heekin, D Shorter, TR Kosten - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Substance use disorders (SUD) are a significant threat to both individual and
public health. To date, SUD pharmacotherapy has focused primarily on agonist medications …
public health. To date, SUD pharmacotherapy has focused primarily on agonist medications …
Engineering of a hybrid nanoparticle-based nicotine nanovaccine as a next-generation immunotherapeutic strategy against nicotine addiction: A focus on hapten …
Although vaccination is a promising way to combat nicotine addiction, most traditional
hapten-protein conjugate nicotine vaccines only show limited efficacy due to their poor …
hapten-protein conjugate nicotine vaccines only show limited efficacy due to their poor …
The effect of preexisting anti-carrier immunity on subsequent responses to CRM197 or Qb-VLP conjugate vaccines
MJ McCluskie, DM Evans, N Zhang… - …, 2016 - Taylor & Francis
Context: Certain antigens, such as haptens (small molecules), short peptides, and
carbohydrates (eg bacterial polysaccharides) are non-or poorly immunogenic unless …
carbohydrates (eg bacterial polysaccharides) are non-or poorly immunogenic unless …
Peptide-free synthetic nicotine vaccine candidates with α-galactosylceramide as adjuvant
XZ Chen, RY Zhang, XF Wang, XG Yin… - Molecular …, 2019 - ACS Publications
Peptides are generally needed as T-helper epitopes in nicotine vaccines to induce effective
antibody responses, but the highly polymorphic property of major histocompatibility complex …
antibody responses, but the highly polymorphic property of major histocompatibility complex …
Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models
The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …
and an exponential rise in electronic cigarette use. No new nicotine cessation …