Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …

The lack of new antibiotics necessitates the improvement of existing ones, many of which
are limited by toxic side effects. Aminoglycosides, antibiotics with excellent activity and low …

Gentamicin-induced nephrotoxicity has been well documented, although its underlying
mechanisms and preventive strategies remain to be investigated. The present study was …

The aminoglycoside antibiotic gentamicin (GM) is still widely used against infections by
Gram‐positive and Gram‐negative aerobic bacteria. Its therapeutic efficacy, however, is …

The staggering cost of bringing a drug to market coupled with the extremely high failure rate
of prospective compounds in early phase clinical trials due to unexpected human toxicity …

The most important reason for the non-approval and withdrawal of drugs by the Food and
Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the …

Gentamicin is commonly used against gram-negative microorganisms. Its therapeutic use is
mainly limited by nephrotoxicity. This study was aimed at evaluating the effect of rutin on …

BACKGROUND: Kidney is known as the most sensitive target organ for depleted uranium
(DU) toxicity in comparison to other organs. Although the oxidative stress and mitochondrial …

Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity.
Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological …