Sleep and anxiety: From mechanisms to interventions
SL Chellappa, D Aeschbach - Sleep medicine reviews, 2022 - Elsevier
Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …
Insomnia as a predictor of mental disorders: a systematic review and meta-analysis
E Hertenstein, B Feige, T Gmeiner, C Kienzler… - Sleep medicine …, 2019 - Elsevier
Previous research has identified insomnia as a predictor for the onset of depression. The
aim of this meta-analysis is to investigate whether insomnia also predicts the onset of other …
aim of this meta-analysis is to investigate whether insomnia also predicts the onset of other …
The role of the locus coeruleus in the generation of pathological anxiety
This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …
[HTML][HTML] Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …
many fundamental brain functions. Studies in humans have suggested that strong LC …
Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and …
The current report provides an updated review of sleep disturbance in posttraumatic stress
disorder and anxiety-related disorders. First, this review provides a summary description of …
disorder and anxiety-related disorders. First, this review provides a summary description of …
[HTML][HTML] Noradrenergic modulation of fear conditioning and extinction
TF Giustino, S Maren - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and
memory. Here we begin with an overview of the LC-NE system. We then consider how both …
memory. Here we begin with an overview of the LC-NE system. We then consider how both …
[HTML][HTML] To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling
condition resulting in a reduced quality of life and increased economic burden. The disorder …
condition resulting in a reduced quality of life and increased economic burden. The disorder …
[HTML][HTML] Real-world stress resilience is associated with the responsivity of the locus coeruleus
M Grueschow, N Stenz, H Thörn, U Ehlert… - Nature …, 2021 - nature.com
Individuals may show different responses to stressful events. Here, we investigate the
neurobiological basis of stress resilience, by showing that neural responsitivity of the …
neurobiological basis of stress resilience, by showing that neural responsitivity of the …
Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning
Stress impairs extinction learning, and these deficits depend, in part, on stress-induced
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
Effects of reciprocal inhibition and whole‐body relaxation on persistent inward currents estimated by two different methods
Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of
motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by …
motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by …