RAS proteins are monomeric GTPases that act as binary molecular switches to regulate a
wide range of cellular processes. The exchange of GTP for GDP on RAS is regulated by …

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

Except for the role of NO in the activation of guanylate cyclase, which is well established, the
involvement of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in signal …

Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of
functions in both physiology and pathology and within every major organ system. It has …

Angiotensin II (AII) increases production of reactive oxygen species from NAD (P) H oxidase,
a response that contributes to vascular hypertrophy. Here we show in cultured vascular …

Much attention has been paid to nitric oxide (NO) research since its discovery as a
physiological mediator in the cardiovascular system. In recent years, newer roles have been …

During the past several years, major advances have been made in understanding how
reactive oxygen species (ROS) and nitrogen species (RNS) participate in signal …

Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS
proteins integrate signals from a wide array of receptors and initiate downstream signaling …

The biological effects of nitric oxide (NO) are in significant part mediated through S-
nitrosylation of cysteine thiol. Work on model thiol substrates has raised the idea that …

The three human RAS genes encode four proteins that play central roles in oncogenesis by
acting as binary molecular switches that regulate signaling pathways for growth and …