Poultry in commercial settings are exposed to a range of stressors. A growing body of
information clearly indicates that excess ROS/RNS production and oxidative stress are …

Ferroptosis is a novel regulated cell death pattern discovered when studying the mechanism
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …

Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various
flavonolignans (with silybin being the major one), has received a tremendous amount of …

The global popularity of herbal supplements and the promise they hold in treating various
disease states has caused an unprecedented interest in understanding the molecular basis …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

A variety of antioxidant compounds derived from natural products (nutraceuticals) have
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Significance: A vast amount of circumstantial evidence implicates high energy oxidants and
oxidative stress as mediators of secondary damage associated with traumatic brain injury …

The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale
is that their antioxidant activity would prevent free radical damage to macromolecules …