Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency...

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[HTML][HTML] Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

T He, L Xiao, Y Qiao, O Klingbeil, E Young, XS Wu… - Cancer Cell, 2024 - cell.com
Summary The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
被引用次数：8 相关文章 所有 6 个版本

Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity

E Redin, Á Quintanal-Villalonga, CM Rudin - Trends in Cancer, 2024 - cell.com
Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …
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SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

E Redin, H Sridhar, YA Zhan, B Pereira Mello… - Journal of Hematology & …, 2024 - Springer
Abstract Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional
subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence …
被引用次数：1 相关文章 所有 8 个版本

Transcription factor dependencies identify BAF-dependent cancers

HM McRae, DC Hargreaves - Cancer Cell, 2024 - Elsevier
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are
dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple …
相关文章 所有 3 个版本