Peptide based antimicrobials: Design strategies and therapeutic potential

PK Hazam, R Goyal, V Ramakrishnan - Progress in biophysics and …, 2019 - Elsevier
Therapeutic activity of antibiotics is noteworthy, as they are used in the treatment of microbial
infections. Regardless of their utility, there has been a steep decrease in the number of drug …

An atlas of anionic antimicrobial peptides from amphibians

SR Dennison, F Harris, M Mura… - Current Protein and …, 2018 - ingentaconnect.com
Anionic antimicrobial peptides (AAMPs) with net charges ranging from-1 to-8 have been
identified in frogs, toads, newts and salamanders across Africa, South America and China …

pH-responsive antimicrobial peptide with selective killing activity for bacterial abscess therapy

Z Wang, Q Li, J Li, L Shang, J Li, S Chou… - Journal of Medicinal …, 2022 - ACS Publications
The unusual acidic pH of the abscess milieu is an adverse factor that decreases the
therapeutic efficacy of traditional antibiotics. Moreover, avoiding both the undesired killing of …

Assessing barriers for antimicrobial penetration in complex asymmetric bacterial membranes: A case study with thymol

P Sharma, S Parthasarathi, N Patil, M Waskar, JS Raut… - Langmuir, 2020 - ACS Publications
The bacterial cell envelope is a complex multilayered structure evolved to protect bacteria in
hostile environments. An understanding of the molecular basis for the interaction and …

Growth-phase dependence of bacterial membrane lipid profile and labeling for in-cell solid-state NMR applications

F Laydevant, M Mahabadi, P Llido… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Cell labeling is a preliminary step in multiple biophysical approaches, including the solid-
state nuclear magnetic resonance (NMR) study of bacteria in vivo. Deuterium solid-state …

The intricate link between membrane lipid structure and composition and membrane structural properties in bacterial membranes

TH Lee, P Charchar, F Separovic, GE Reid… - Chemical …, 2024 - pubs.rsc.org
It is now evident that the cell manipulates lipid composition to regulate different processes
such as membrane protein insertion, assembly and function. Moreover, changes in …

Neutrons and model membranes: Moving towards complexity

G Fragneto, R Delhom, L Joly, E Scoppola - Current opinion in colloid & …, 2018 - Elsevier
Cells, the basic units of living organisms, are well delineated and separated from the
external environment by membranes. Capable of both enclosing the cellular constituents …

Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery

M Song, S Chen, W Lin, K Zhu - Progress in Lipid Research, 2024 - Elsevier
Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens
pose a serious threat to public health. New antibacterial targets are extremely urgent to …

A Methylazanediyl Bisacetamide Derivative Sensitizes Staphylococcus aureus Persisters to a Combination of Gentamicin And Daptomycin

HY Heo, G Zou, S Baek, JS Kim, E Mylonakis… - Advanced …, 2024 - Wiley Online Library
Infections caused by Staphylococcus aureus, notably methicillin‐resistant S. aureus
(MRSA), pose treatment challenges due to its ability to tolerate antibiotics and develop …

Phase Diagram for a Lysyl‐Phosphatidylglycerol Analogue in Biomimetic Mixed Monolayers with Phosphatidylglycerol: Insights into the Tunable Properties of …

C Wölk, H Youssef, T Guttenberg, H Marbach… - …, 2020 - Wiley Online Library
Ion pairing between the major phospholipids of the Staphylococcus aureus plasma
membrane (phosphatidylglycerol–PG and lysyl‐phosphatidylglycerol–LPG) confers …