Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
A complex systems approach to aging biology
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …
aging biology research is now moving toward integration of these parts, attempting to …
miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …
how and why aging turns out to be the main risk factor for the development of the most …
Intrinsic capacity: validation of a new WHO concept for healthy aging in a longitudinal Chinese study
Abstract Background The World Health Organization has proposed a model of healthy aging
built around the concept of functional ability, comprising an individual's intrinsic capacity, the …
built around the concept of functional ability, comprising an individual's intrinsic capacity, the …
WHO working definition of vitality capacity for healthy longevity monitoring
I Bautmans, V Knoop, JA Thiyagarajan… - The lancet Healthy …, 2022 - thelancet.com
Intrinsic capacity, a crucial concept in healthy ageing, is defined by WHO as" the composite
of all the physical and mental capacities that an individual can draw on at any point in time" …
of all the physical and mental capacities that an individual can draw on at any point in time" …
Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
[HTML][HTML] Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension
SK Soo, ZD Rudich, B Ko, A Moldakozhayev… - Ageing Research …, 2023 - Elsevier
While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …
now clear that aging is strongly influenced by genetics. The identification and …
The conundrum of human immune system “senescence”
There is a great deal of debate on the question of whether or not we know what ageing is
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …
Aging and mesenchymal stem cells: basic concepts, challenges and strategies
M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …
mechanisms, which demand for new therapeutic strategies against their devastating effects …