Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

[HTML][HTML] Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development

X Wang, Y Hou, X Ai, J Sun, B Xu, X Meng… - Biomedicine & …, 2020 - Elsevier
The human blood-brain barrier (BBB) is a complex multi-dimensional reticular barrier system
composed of cerebral microvascular endothelial cells, pericytes, astrocytes and a variety of …

A polymeric microfluidic device integrated with nanoporous alumina membranes for simultaneous detection of multiple foodborne pathogens

F Tian, J Lyu, J Shi, F Tan, M Yang - Sensors and Actuators B: Chemical, 2016 - Elsevier
Conventional biochemical methods for foodborne pathogen detection are time-consuming,
labor-intensive and can only be used for single type bacteria detection with one sample …

Recent development of microfluidics-based platforms for respiratory virus detection

J Shi, Y Zhang, M Yang - Biomicrofluidics, 2023 - pubs.aip.org
With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology
for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive …

Microfluidic synthesis of nanoparticles and their biosensing applications

J Boken, SK Soni, D Kumar - Critical reviews in analytical …, 2016 - Taylor & Francis
We present an extensive overview of the evolution and progress made in the field of
microstructures and nanostructures preparation using microfluidic techniques in recent …

Microfluidic-based single-cell study: current status and future perspective

H Wu, J Zhu, Y Huang, D Wu, J Sun - Molecules, 2018 - mdpi.com
Investigation of cell behavior under different environments and manual operations can give
information in specific cellular processes. Among all cell-based analysis, single-cell study …

" MS-patch-clamp" or the possibility of mass spectrometry hybridization with patch-clamp setups for single cell metabolomics and channelomics

OV Gradov, MA Gradova - arXiv preprint arXiv:1511.06997, 2015 - arxiv.org
In this projecting work we propose a mass spectrometric patch-clamp equipment with the
capillary performing both a local potential registration at the cell membrane and the analyte …

Priming and testing silicon patch-clamp neurochips

C Py, MW Denhoff, N Sabourin, J Weber, M Shiu… - New biotechnology, 2014 - Elsevier
Highlights•We have developed an automated priming and testing setup for silicon patch-
clamp chips.•90% of chips are successfully primed.•There is a wide discrepancy in terms of …

Research Progress of Cell Electrophysiological Recordings

F Hou, H Yang, J Wang, B Wang, J Hu… - 2022 16th ICME …, 2022 - ieeexplore.ieee.org
The study of the electrical properties of biological cells is of crucial importance for the
prevention and treatment of diseases. The detection of electrical properties of cells provides …

Surface characteristics and electrical properties of PMMA chips for incubation-type planar-patch-clamp biosensors

S Obuliraj, N Takada, Z Wang, K Kobayashi… - Colloids and Surfaces B …, 2014 - Elsevier
Polymethylmethacrylate (PMMA) plates were successfully applied as sensor chips in an
incubation-type planar patch clamp (IPPC). Hot embossing both sides formed the PMMA …