Translational control in aging and neurodegeneration
Protein metabolism plays central roles in age‐related decline and neurodegeneration. While
a large body of research has explored age‐related changes in protein degradation …
a large body of research has explored age‐related changes in protein degradation …
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation
NV Licata, R Cristofani, S Salomonsson… - The EMBO …, 2022 - embopress.org
Abstract Intronic GGGGCC (G4C2) hexanucleotide repeat expansion within the human
C9orf72 gene represents the most common cause of familial forms of amyotrophic lateral …
C9orf72 gene represents the most common cause of familial forms of amyotrophic lateral …
Identifying modulators of C9orf72 DPRs and STMN2 levels in ALS/FTD using high throughput screening
BV Holbling - 2023 - discovery.ucl.ac.uk
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases on the same continuum. In this thesis, I will focus on two key …
neurodegenerative diseases on the same continuum. In this thesis, I will focus on two key …