Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple
cardiac cell lineages during embryonic development and provides signals that are essential …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The …

Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and
developmentally plastic mesenchymal cells. All cells in the heart arise from one or more …