A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …
medicine. Resources such as imputation reference panels that match the study population …
Selection against admixture and gene regulatory divergence in a long-term primate field study
Genetic admixture is central to primate evolution. We combined 50 years of field
observations of immigration and group demography with genomic data from~ 9 generations …
observations of immigration and group demography with genomic data from~ 9 generations …
A comparison of humans and baboons suggests germline mutation rates do not track cell divisions
In humans, most germline mutations are inherited from the father. This observation has been
widely interpreted as reflecting the replication errors that accrue during spermatogenesis. If …
widely interpreted as reflecting the replication errors that accrue during spermatogenesis. If …
Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements
Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …
Landscape genomics analysis provides insights into future climate change-driven risk in rhesus macaque
R Wu, J Qi, W Li, L Wang, Y Shen, J Liu, Y Teng… - Science of the Total …, 2023 - Elsevier
Climate change significantly affects the suitability of wildlife habitats. Thus, understanding
how animals adapt ecologically and genetically to climate change is important for targeted …
how animals adapt ecologically and genetically to climate change is important for targeted …
Admixture in mammals and how to understand its functional implications: on the abundance of gene flow in mammalian species, its impact on the genome, and roads …
Admixture, the genetic exchange between differentiated populations appears to be common
in the history of species, but has not yet been comparatively studied across mammals. This …
in the history of species, but has not yet been comparatively studied across mammals. This …
Insights into the evolution of social systems and species from baboon studies
Baboons, members of the genus Papio, comprise six closely related species distributed
throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological …
throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological …
Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF
V Ibanez, K Vaitkus, X Zhang, J Ramasamy… - Blood …, 2023 - ashpublications.org
Increased fetal hemoglobin (HbF) levels reduce the symptoms of sickle cell disease (SCD)
and increase the lifespan of patients. Because curative strategies for bone marrow …
and increase the lifespan of patients. Because curative strategies for bone marrow …
Assessing the recovery of Y chromosome microsatellites with population genomic data using Papio and Theropithecus genomes
Y chromosome markers can shed light on male-specific population dynamics but for many
species no such markers have been discovered and are available yet, despite the potential …
species no such markers have been discovered and are available yet, despite the potential …
Mechanisms of inbreeding avoidance in a wild primate
Inbreeding often imposes net fitness costs, 1–5 leading to the expectation that animals will
engage in inbreeding avoidance when the costs of doing so are not prohibitive. 4–9 …
engage in inbreeding avoidance when the costs of doing so are not prohibitive. 4–9 …