A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

J Choi, S Kim, J Kim, HY Son, SK Yoo, CU Kim… - Science …, 2023 - science.org
Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

Selection against admixture and gene regulatory divergence in a long-term primate field study

TP Vilgalys, AS Fogel, JA Anderson, RS Mututua… - Science, 2022 - science.org
Genetic admixture is central to primate evolution. We combined 50 years of field
observations of immigration and group demography with genomic data from~ 9 generations …

A comparison of humans and baboons suggests germline mutation rates do not track cell divisions

FL Wu, AI Strand, LA Cox, C Ober, JD Wall… - PLoS …, 2020 - journals.plos.org
In humans, most germline mutations are inherited from the father. This observation has been
widely interpreted as reflecting the replication errors that accrue during spermatogenesis. If …

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

DA Murphy, E Elyashiv, G Amster, G Sella - Elife, 2022 - elifesciences.org
Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …

Landscape genomics analysis provides insights into future climate change-driven risk in rhesus macaque

R Wu, J Qi, W Li, L Wang, Y Shen, J Liu, Y Teng… - Science of the Total …, 2023 - Elsevier
Climate change significantly affects the suitability of wildlife habitats. Thus, understanding
how animals adapt ecologically and genetically to climate change is important for targeted …

Admixture in mammals and how to understand its functional implications: on the abundance of gene flow in mammalian species, its impact on the genome, and roads …

C Fontsere, M de Manuel, T Marques‐Bonet… - …, 2019 - Wiley Online Library
Admixture, the genetic exchange between differentiated populations appears to be common
in the history of species, but has not yet been comparatively studied across mammals. This …

Insights into the evolution of social systems and species from baboon studies

J Fischer, JP Higham, SC Alberts, L Barrett… - Elife, 2019 - elifesciences.org
Baboons, members of the genus Papio, comprise six closely related species distributed
throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological …

Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF

V Ibanez, K Vaitkus, X Zhang, J Ramasamy… - Blood …, 2023 - ashpublications.org
Increased fetal hemoglobin (HbF) levels reduce the symptoms of sickle cell disease (SCD)
and increase the lifespan of patients. Because curative strategies for bone marrow …

Assessing the recovery of Y chromosome microsatellites with population genomic data using Papio and Theropithecus genomes

G Mutti, G Oteo-Garcia, M Caldon, MJF da Silva… - Scientific Reports, 2023 - nature.com
Y chromosome markers can shed light on male-specific population dynamics but for many
species no such markers have been discovered and are available yet, despite the potential …

Mechanisms of inbreeding avoidance in a wild primate

AA Galezo, MA Nolas, AS Fogel, RS Mututua… - Current Biology, 2022 - cell.com
Inbreeding often imposes net fitness costs, 1–5 leading to the expectation that animals will
engage in inbreeding avoidance when the costs of doing so are not prohibitive. 4–9 …