Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was
commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline …

Biofilms—communities of bacteria encased in a polymer-rich matrix—confer bacteria with
the ability to persist in pathologic host contexts, such as the cystic fibrosis (CF) airways. How …

Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Bronchiectasis is a disease of renewed interest in light of an increase in prevalence and
increasing burden on international healthcare systems. There are no licensed therapies …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

The widespread use of antibiotics promotes the evolution and dissemination of resistance
and tolerance mechanisms. To assess the relevance of tolerance and its implications for …

1. Executive summary Multi-drug-resistant (MDR) Gram-negative bacterial infections have
become prevalent in some European countries. Moreover, increased use of broad-spectrum …