Bioactive synthetic polymers

K Jung, N Corrigan, EHH Wong, C Boyer - Advanced Materials, 2022 - Wiley Online Library
Synthetic polymers are omnipresent in society as textiles and packaging materials, in
construction and medicine, among many other important applications. Alternatively, natural …

Approaches for the inhibition and elimination of microbial biofilms using macromolecular agents

LD Blackman, Y Qu, P Cass, KES Locock - Chemical Society Reviews, 2021 - pubs.rsc.org
Biofilms are complex three-dimensional structures formed at interfaces by the vast majority
of bacteria and fungi. These robust communities have an important detrimental impact on a …

Biomimetic antimicrobial polymers: Recent advances in molecular design

C Ergene, K Yasuhara, EF Palermo - Polymer Chemistry, 2018 - pubs.rsc.org
The increasing prevalence of antibiotic-resistant bacterial infections, coupled with the
decline in the number of new antibiotic drug approvals, has created a therapeutic gap that …

Synthetic antimicrobial polymers in combination therapy: tackling antibiotic resistance

R Namivandi-Zangeneh, EHH Wong… - ACS Infectious …, 2021 - ACS Publications
Antibiotic resistance is a critical global healthcare issue that urgently needs new effective
solutions. While small molecule antibiotics have been safeguarding us for nearly a century …

Towards sequence‐controlled antimicrobial polymers: effect of polymer block order on antimicrobial activity

PR Judzewitsch, TK Nguyen… - Angewandte Chemie …, 2018 - Wiley Online Library
Synthetic polymers have shown promise in combating multidrug‐resistant bacteria.
However, the biological effects of sequence control in synthetic antimicrobial polymers are …

Design of antimicrobial polymers

P Pham, S Oliver, C Boyer - Macromolecular Chemistry and …, 2023 - Wiley Online Library
Antibiotic resistance has become a critical issue, alarming the healthcare and agriculture
sectors worldwide. Thanks to rapid advancements in polymer science, antimicrobial …

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides

P Salas-Ambrosio, A Tronnet, P Verhaeghe… - …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …

Geared toward applications: A perspective on functional sequence-controlled polymers

C Yang, KB Wu, Y Deng, J Yuan, J Niu - ACS macro letters, 2021 - ACS Publications
Sequence-controlled polymers are an emerging class of synthetic polymers with a regulated
sequence of monomers. In the past decade, tremendous progress has been made in the …

Concurrent control over sequence and dispersity in multiblock copolymers

MN Antonopoulou, R Whitfield, NP Truong, D Wyers… - Nature Chemistry, 2022 - nature.com
Controlling monomer sequence and dispersity in synthetic macromolecules is a major goal
in polymer science as both parameters determine materials' properties and functions …

Effect of hydrophobic groups on antimicrobial and hemolytic activity: Developing a predictive tool for ternary antimicrobial polymers

PT Phuong, S Oliver, J He, EHH Wong… - …, 2020 - ACS Publications
Antimicrobial polymers have emerged as a potential solution to the growing problem of
antimicrobial resistance. Although several studies have examined the effects of various …