Currently, there is an increasing focus on comprehending the solubility of plant-based
proteins, driven by the rising demand for animal-free food formulations. The solubility of …

Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

Background Accurate estimation of the isoelectric point (pI) based on the amino acid
sequence is useful for many analytical biochemistry and proteomics techniques such as 2-D …

Proteome-pI is an online database containing information about predicted isoelectric points
for 5029 proteomes calculated using 18 methods. The isoelectric point, the pH at which a …

The isoelectric point is the pH at which a particular molecule is electrically neutral due to the
equilibrium of positive and negative charges. In proteins and peptides, this depends on the …

The goal of this article is to summarize what has been learned about the major forces
stabilizing proteins since the late 1980s when site-directed mutagenesis became possible …

Background Charge states of ionizable residues in proteins determine their pH-dependent
properties through their pK a values. Thus, various theoretical methods to determine …

Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with
repetitive segments flanked by conserved non-repetitive domains,. Spidroins are stored as a …