Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Telomeres are protective structures present at the ends of linear chromosomes that are
important in preventing genome instability. Telomeres shorten as a result of cellular …

Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased
senescent cell burden in various tissues is a major contributor to aging and age-related …

Telomere shortening to a critical length can trigger aging and shorter life spans in mice and
humans by a mechanism that involves induction of a persistent DNA damage response at …

Medical pain management is in crisis; from the pervasiveness of pain to inadequate pain
treatment, from the escalation of prescription opioids to an epidemic in addiction, diversion …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

Animal response to stressors such as harsh environmental conditions and demanding
biological processes requires energy generated through increased mitochondrial activity …

Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …