MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci. Recent work suggested that rather than up-and downregulating selected …

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of
the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) …

Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is
essential in many processes, including tissue sculpting during embryogenesis, development …

To date, more than 200 microRNAs have been described in humans; however, the precise
functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in
adults, is still largely unknown. The full spectrum of genetic lesions that are present in the …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …