Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA,
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …
Readers, writers and erasers of N6-methylated adenosine modification
Highlights•The highly dynamic landscape of reversible m 6 A modifications on internal sites
of RNAs contributes to the complexity of epitranscriptome.•Crystal structures of m 6 A writers …
of RNAs contributes to the complexity of epitranscriptome.•Crystal structures of m 6 A writers …
Dynamic readers for 5-(hydroxy) methylcytosine and its oxidized derivatives
CG Spruijt, F Gnerlich, AH Smits, T Pfaffeneder… - Cell, 2013 - cell.com
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins
C Xu, K Liu, H Ahmed, P Loppnau, M Schapira… - Journal of Biological …, 2015 - ASBMB
N 6-Methyladenosine (m 6 A) is the most abundant internal modification in RNA and is
specifically recognized by YT521-B homology (YTH) domain-containing proteins. Recently …
specifically recognized by YT521-B homology (YTH) domain-containing proteins. Recently …
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
Methylation of the N6 position of selected internal adenines (m6A) in mRNAs and noncoding
RNAs is widespread in eukaryotes, and the YTH domain in a collection of proteins …
RNAs is widespread in eukaryotes, and the YTH domain in a collection of proteins …
Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA
Discovery of the TET/JBP family of dioxygenases that modify bases in DNA has sparked
considerable interest in novel DNA base modifications and their biological roles. Using …
considerable interest in novel DNA base modifications and their biological roles. Using …
Structural Insights into N6-Methyladenosine (m6A) Modification in the Transcriptome
J Huang, P Yin - Genomics, Proteomics and Bioinformatics, 2018 - academic.oup.com
More than 100 types of chemical modifications in RNA have been well documented.
Recently, several modifications, such as N 6-methyladenosine (m6A), have been detected in …
Recently, several modifications, such as N 6-methyladenosine (m6A), have been detected in …
Structural genomics is the largest contributor of novel structural leverage
R Nair, J Liu, TT Soong, TB Acton, JK Everett… - Journal of structural and …, 2009 - Springer
Abstract The Protein Structural Initiative (PSI) at the US National Institutes of Health (NIH) is
funding four large-scale centers for structural genomics (SG). These centers systematically …
funding four large-scale centers for structural genomics (SG). These centers systematically …
A protein architecture guided screen for modification dependent restriction endonucleases
T Lutz, K Flodman, A Copelas, H Czapinska… - Nucleic acids …, 2019 - academic.oup.com
Modification dependent restriction endonucleases (MDREs) often have separate catalytic
and modification dependent domains. We systematically looked for previously …
and modification dependent domains. We systematically looked for previously …
An Inducible Microbacterium Prophage vB_MoxS-R1 Represents a Novel Lineage of Siphovirus
H Zheng, B Liu, Y Xu, Z Zhang, H Man, J Liu, F Chen - Viruses, 2022 - mdpi.com
Lytic and lysogenic infections are the main strategies used by viruses to interact with
microbial hosts. The genetic information of prophages provides insights into the nature of …
microbial hosts. The genetic information of prophages provides insights into the nature of …