Dimerization of retroviral RNA genomes: an inseparable pair
JC Paillart, M Shehu-Xhilaga, R Marquet… - Nature Reviews …, 2004 - nature.com
Many viruses carry more than one segment of nucleic acid into the virion particle, but
retroviruses are the only known group of viruses that contain two identical (or nearly …
retroviruses are the only known group of viruses that contain two identical (or nearly …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
HIV‐1 RNA Packaging
AML Lever - Advances in pharmacology, 2007 - Elsevier
Publisher Summary This chapter focuses on the concept of human immunodeficiency virus
type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process …
type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process …
Specific recognition of the HIV-1 genomic RNA by the Gag precursor
EW Abd El-Wahab, RP Smyth, E Mailler… - Nature …, 2014 - nature.com
During assembly of HIV-1 particles in infected cells, the viral Pr55Gag protein (or Gag
precursor) must select the viral genomic RNA (gRNA) from a variety of cellular and viral …
precursor) must select the viral genomic RNA (gRNA) from a variety of cellular and viral …
Short-and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
First snapshots of the HIV-1 RNA structure in infected cells and in virions
JC Paillart, M Dettenhofer, X Yu, C Ehresmann… - Journal of Biological …, 2004 - ASBMB
With the increasing interest of RNAs in regulating a range of cell biological processes, very
little is known about the structure of RNAs in tissue culture cells. We focused on the 5 …
little is known about the structure of RNAs in tissue culture cells. We focused on the 5 …
RNA structure and packaging signals in the 5′ leader region of the human immunodeficiency virus type 1 genome
JL Clever, D Miranda Jr, TG Parslow - Journal of virology, 2002 - Am Soc Microbiol
The leader region of the human immunodeficiency virus type 1 (HIV-1) genome has a highly
folded structure, comprising at least two RNA stem-loops [the transactivation response (TAR) …
folded structure, comprising at least two RNA stem-loops [the transactivation response (TAR) …
HIV-1 Pr55Gag binds genomic and spliced RNAs with different affinity and stoichiometry
S Bernacchi, EW Abd El-Wahab, N Dubois, M Hijnen… - RNA biology, 2017 - Taylor & Francis
ABSTRACT The HIV-1 Pr55Gag precursor specifically selects genomic RNA (gRNA) from a
large variety of cellular and spliced viral RNAs (svRNAs), however the molecular …
large variety of cellular and spliced viral RNAs (svRNAs), however the molecular …
In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes
B Berkhout, M Ooms, N Beerens, H Huthoff… - Journal of Biological …, 2002 - ASBMB
The HIV-1 RNA genome forms dimers through base pairing of a palindromic 6-mer
sequence that is exposed in the loop of the dimer initiation signal (DIS) hairpin structure …
sequence that is exposed in the loop of the dimer initiation signal (DIS) hairpin structure …
Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging
JI Sakuragi, S Ueda, A Iwamoto, T Shioda - Journal of virology, 2003 - Am Soc Microbiol
The dimer initiation site/dimer linkage sequence (DIS/DLS) region in the human
immunodeficiency virus type 1 (HIV-1) RNA genome is suggested to play important roles in …
immunodeficiency virus type 1 (HIV-1) RNA genome is suggested to play important roles in …