The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short
of revealing the complete genomic landscape of a tumour. With an expanding repertoire of …

Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200
years of study, the process of tumor metastasis remains controversial. Stephen Paget initially …

Researchers have been studying metastasis for more than 100 years, and only recently
have we gained insight into the mechanisms by which metastatic cells arise from primary …

Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used
multiphoton laser scanning microscopy to image the single steps of metastasis formation in …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

The major cause of cancer-associated mortality is tumor metastasis, a disease that is far
from understood. Many studies have observed circulating tumor cells (CTCs) in patients' …

Many studies have shown that primary prostate cancers are multifocal,, and are composed
of multiple genetically distinct cancer cell clones,,. Whether or not multiclonal primary …

The importance of cancer stem cells (CSCs) in tumor-initiation has been firmly established in
leukemia and recently reported for a variety of solid tumors. However, the role of CSCs in …