Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous
medicinal plants and has an array of pharmacological properties. It has been used in …

Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe
adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of …

Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and
Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized …

Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

The clinical application of doxorubicin (DOX) for cancer treatment is limited due to its
cardiotoxicity. However, the basic pathophysiological molecular mechanisms underlying …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …

With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …