Two hormones for one receptor: evolution, biochemistry, actions, and pathophysiology of LH and hCG
LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development
and reproduction. Because they act on the same receptor (LHCGR), the general consensus …
and reproduction. Because they act on the same receptor (LHCGR), the general consensus …
Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses
AM Carter - Physiological reviews, 2012 - journals.physiology.org
Placenta has a wide range of functions. Some are supported by novel genes that have
evolved following gene duplication events while others require acquisition of gene …
evolved following gene duplication events while others require acquisition of gene …
[HTML][HTML] Recent advances in understanding gonadotropin signaling
L Casarini, M Simoni - Faculty reviews, 2021 - ncbi.nlm.nih.gov
Gonadotropins are glycoprotein sex hormones regulating development and reproduction
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …
Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor
B Troppmann, G Kleinau, G Krause… - Human reproduction …, 2013 - academic.oup.com
BACKGROUND In recent years it became evident that several types of the luteinizing
hormone/choriogonadotrophin receptor (LHCGR) exist. In addition to the classical receptor …
hormone/choriogonadotrophin receptor (LHCGR) exist. In addition to the classical receptor …
[HTML][HTML] Genomics and genetics of gonadotropin beta-subunit genes: Unique FSHB and duplicated LHB/CGB loci
The follicle stimulating hormone (FSH), luteinizing hormone (LH) and chorionic
gonadotropin (HCG) play a critical role in human reproduction. Despite the common …
gonadotropin (HCG) play a critical role in human reproduction. Despite the common …
The evolution and expression of the snaR family of small non-coding RNAs
AM Parrott, M Tsai, P Batchu, K Ryan… - Nucleic acids …, 2011 - academic.oup.com
We recently identified the snaR family of small non-coding RNAs that associate in vivo with
the nuclear factor 90 (NF90/ILF3) protein. The major human species, snaR-A, is an RNA …
the nuclear factor 90 (NF90/ILF3) protein. The major human species, snaR-A, is an RNA …
[HTML][HTML] Extensive load of somatic CNVs in the human placenta
Placenta is a temporary, but indispensable organ in mammalian pregnancy. From its basic
nature, it exhibits highly invasive tumour-like properties facilitating effective implantation …
nature, it exhibits highly invasive tumour-like properties facilitating effective implantation …
The origins and evolution of genetic disease risk in modern humans
BJ Crespi - Annals of the New York Academy of Sciences, 2010 - Wiley Online Library
Patterns and risks of human disease have evolved. In this article, I review evidence
regarding the importance of recent adaptive evolution, positive selection, and genomic …
regarding the importance of recent adaptive evolution, positive selection, and genomic …
[HTML][HTML] Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid
M Lu, R Bränström, E Berglund… - Journal of …, 2010 - jme.bioscientifica.com
Successful human embryo implantation requires a proper differentiation of endometrial
stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs …
stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs …
Structural and functional analysis of rare missense mutations in human chorionic gonadotrophin β-subunit
Heterodimeric hCG is one of the key hormones determining early pregnancy success. We
have previously identified rare missense mutations in hCGβ genes with potential …
have previously identified rare missense mutations in hCGβ genes with potential …