[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up
MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …
opportunities for biomedical research. Although several PLGA-based systems have already …
[HTML][HTML] A review of microfluidic experimental designs for nanoparticle synthesis
AG Niculescu, DE Mihaiescu… - International Journal of …, 2022 - mdpi.com
Microfluidics is defined as emerging science and technology based on precisely
manipulating fluids through miniaturized devices with micro-scale channels and chambers …
manipulating fluids through miniaturized devices with micro-scale channels and chambers …
Ionizable lipid nanoparticles for in utero mRNA delivery
RS Riley, MV Kashyap, MM Billingsley, B White… - Science …, 2021 - science.org
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
[HTML][HTML] In vivo clearance of 19F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure
Perfluorocarbons hold great promise both as imaging agents, particularly for 19 F MRI, and
in therapy, such as oxygen delivery. 19 F MRI is unique in its ability to unambiguously track …
in therapy, such as oxygen delivery. 19 F MRI is unique in its ability to unambiguously track …
[HTML][HTML] p47phox siRNA-Loaded PLGA nanoparticles suppress ROS/oxidative stress-induced chondrocyte damage in osteoarthritis
HJ Shin, H Park, N Shin, HH Kwon, Y Yin, JA Hwang… - Polymers, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disorder that has had an increasing prevalence
due to the aging of the population. Recent studies have concluded that OA progression is …
due to the aging of the population. Recent studies have concluded that OA progression is …
[HTML][HTML] PLGA based drug carrier and pharmaceutical applications: the most recent advances
JA Loureiro, MC Pereira - Pharmaceutics, 2020 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successful polymers that has been
used to produce medicines, such as drug carriers (DC). This is one of the few polymers that …
used to produce medicines, such as drug carriers (DC). This is one of the few polymers that …
A comprehensive review of one decade of microfluidic platforms applications in synthesis of enhanced carriers utilized in controlled drug delivery
Novel nanocarriers such as multifunctional nanoparticles (NPs) have recently attracted
attention due to their various applications, specifically in medicine and treatment. However, it …
attention due to their various applications, specifically in medicine and treatment. However, it …
[HTML][HTML] Industrial scale manufacturing and downstream processing of PLGA-based nanomedicines suitable for fully continuous operation
MC Operti, A Bernhardt, V Sincari, E Jager, S Grimm… - Pharmaceutics, 2022 - mdpi.com
Despite the efficacy and potential therapeutic benefits that poly (lactic-co-glycolic
acid)(PLGA) nanomedicine formulations can offer, challenges related to large-scale …
acid)(PLGA) nanomedicine formulations can offer, challenges related to large-scale …
Core-shell micro/nanocapsules: from encapsulation to applications
Encapsulation is the way to wrap or coat one substance as a core inside another tiny
substance known as a shell at micro and nano scale for protecting the active ingredients …
substance known as a shell at micro and nano scale for protecting the active ingredients …
PLGA nanoparticles enhanced cardio-protection of scutellarin and paeoniflorin against isoproterenol-induced myocardial ischemia in rats
C Yang, S Yang, S Fang, L Li, J Jing, W Liu… - International Journal of …, 2023 - Elsevier
This study aims to examine the impact of the microfluidic preparation process on the quality
of poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) co-delivered with scutellarin …
of poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) co-delivered with scutellarin …