[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …

[HTML][HTML] A review of microfluidic experimental designs for nanoparticle synthesis

AG Niculescu, DE Mihaiescu… - International Journal of …, 2022 - mdpi.com
Microfluidics is defined as emerging science and technology based on precisely
manipulating fluids through miniaturized devices with micro-scale channels and chambers …

Ionizable lipid nanoparticles for in utero mRNA delivery

RS Riley, MV Kashyap, MM Billingsley, B White… - Science …, 2021 - science.org
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …

[HTML][HTML] In vivo clearance of 19F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure

AHJ Staal, K Becker, O Tagit, NK Van Riessen… - Biomaterials, 2020 - Elsevier
Perfluorocarbons hold great promise both as imaging agents, particularly for 19 F MRI, and
in therapy, such as oxygen delivery. 19 F MRI is unique in its ability to unambiguously track …

[HTML][HTML] p47phox siRNA-Loaded PLGA nanoparticles suppress ROS/oxidative stress-induced chondrocyte damage in osteoarthritis

HJ Shin, H Park, N Shin, HH Kwon, Y Yin, JA Hwang… - Polymers, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disorder that has had an increasing prevalence
due to the aging of the population. Recent studies have concluded that OA progression is …

[HTML][HTML] PLGA based drug carrier and pharmaceutical applications: the most recent advances

JA Loureiro, MC Pereira - Pharmaceutics, 2020 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successful polymers that has been
used to produce medicines, such as drug carriers (DC). This is one of the few polymers that …

A comprehensive review of one decade of microfluidic platforms applications in synthesis of enhanced carriers utilized in controlled drug delivery

S Siavashy, M Soltani, M Ahmadi… - Advanced Materials …, 2022 - Wiley Online Library
Novel nanocarriers such as multifunctional nanoparticles (NPs) have recently attracted
attention due to their various applications, specifically in medicine and treatment. However, it …

[HTML][HTML] Industrial scale manufacturing and downstream processing of PLGA-based nanomedicines suitable for fully continuous operation

MC Operti, A Bernhardt, V Sincari, E Jager, S Grimm… - Pharmaceutics, 2022 - mdpi.com
Despite the efficacy and potential therapeutic benefits that poly (lactic-co-glycolic
acid)(PLGA) nanomedicine formulations can offer, challenges related to large-scale …

Core-shell micro/nanocapsules: from encapsulation to applications

E Elkalla, S Khizar, M Tarhini, N Lebaz… - Journal of …, 2023 - Taylor & Francis
Encapsulation is the way to wrap or coat one substance as a core inside another tiny
substance known as a shell at micro and nano scale for protecting the active ingredients …

PLGA nanoparticles enhanced cardio-protection of scutellarin and paeoniflorin against isoproterenol-induced myocardial ischemia in rats

C Yang, S Yang, S Fang, L Li, J Jing, W Liu… - International Journal of …, 2023 - Elsevier
This study aims to examine the impact of the microfluidic preparation process on the quality
of poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) co-delivered with scutellarin …