mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
Recent advancements in liposome technology
The liposomes have continued to be well-recognized as an important nano-sized drug
delivery system with attractive properties, such a characteristic bilayer structure assembling …
delivery system with attractive properties, such a characteristic bilayer structure assembling …
The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
Advances in lipid nanoparticles for mRNA-based cancer immunotherapy
Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines
T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells
S Bevers, SAA Kooijmans, E Van de Velde… - Molecular Therapy, 2022 - cell.com
mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …
Hybrid nanomaterials for cancer immunotherapy
Nano‐immunotherapy has been recognized as a highly promising strategy for cancer
treatment in recent decades, which combines nanotechnology and immunotherapy to …
treatment in recent decades, which combines nanotechnology and immunotherapy to …