Critical review of NGS analyses for de novo genotyping multigene families
The genotyping of highly polymorphic multigene families across many individuals used to be
a particularly challenging task because of methodological limitations associated with …
a particularly challenging task because of methodological limitations associated with …
Mhc supertypes confer both qualitative and quantitative resistance to avian malaria infections in a wild bird population
Major histocompatibility complex (Mhc) genes are believed to play a key role in the genetic
basis of disease control. Although numerous studies have sought links between Mhc and …
basis of disease control. Although numerous studies have sought links between Mhc and …
Ultra‐deep Illumina sequencing accurately identifies MHC class IIb alleles and provides evidence for copy number variation in the guppy (Poecilia reticulata)
J Lighten, C Van Oosterhout… - Molecular Ecology …, 2014 - Wiley Online Library
We address the bioinformatic issue of accurately separating amplified genes of the major
histocompatibility complex (MHC) from artefacts generated during high‐throughput …
histocompatibility complex (MHC) from artefacts generated during high‐throughput …
The Genome of Shaw's Sea Snake (Hydrophis curtus) Reveals Secondary Adaptation to Its Marine Environment
The transition of terrestrial snakes to marine life∼ 10 Ma is ideal for exploring adaptive
evolution. Sea snakes possess phenotype specializations including laterally compressed …
evolution. Sea snakes possess phenotype specializations including laterally compressed …
Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen
J Lighten, AST Papadopulos, RS Mohammed… - Nature …, 2017 - nature.com
Red Queen host–parasite co-evolution can drive adaptations of immune genes by positive
selection that erodes genetic variation (Red Queen arms race) or results in a balanced …
selection that erodes genetic variation (Red Queen arms race) or results in a balanced …
Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection
Deleterious mutations are expected to evolve under negative selection and are usually
purged from the population. However, deleterious alleles segregate in the human …
purged from the population. However, deleterious alleles segregate in the human …
Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula)
The major histocompatibility complex (MHC) is a multigene family responsible for pathogen
detection, and initiation of adaptive immune responses. Duplication, natural selection …
detection, and initiation of adaptive immune responses. Duplication, natural selection …
The impact of translocations on neutral and functional genetic diversity within and among populations of the Seychelles warbler
Translocations are an increasingly common tool in conservation. The maintenance of
genetic diversity through translocation is critical for both the short‐and long‐term persistence …
genetic diversity through translocation is critical for both the short‐and long‐term persistence …
Selective pressures on MHC class II genes in the guppy (Poecilia reticulata) as inferred by hierarchical analysis of population structure
Genes of the major histocompatibility complex, which are the most polymorphic of all
vertebrate genes, are a pre‐eminent system for the study of selective pressures that arise …
vertebrate genes, are a pre‐eminent system for the study of selective pressures that arise …
What mandrills leave behind: using fecal samples to characterize the major histocompatibility complex in a threatened primate
A Weber, J Lighten, C van Oosterhout… - Conservation …, 2024 - Springer
The major histocompatibility complex (MHC) can be useful in guiding conservation planning
because of its influence on immunity, fitness, and reproductive ecology in vertebrates. The …
because of its influence on immunity, fitness, and reproductive ecology in vertebrates. The …