Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

DK Sahoo, RM Heilmann, B Paital, A Patel… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Canine chronic enteropathy—Current state-of-the-art and emerging concepts

AE Jergens, RM Heilmann - Frontiers in Veterinary Science, 2022 - frontiersin.org
Over the last decade, chronic inflammatory enteropathies (CIE) in dogs have received great
attention in the basic and clinical research arena. The 2010 ACVIM Consensus Statement …

Stem cell-derived intestinal organoids: a novel modality for IBD

C Tian, M Yang, H Xu, M Zhu, NN Yue, Y Zhang… - Cell Death …, 2023 - nature.com
The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

Differential transcriptomic profiles following stimulation with lipopolysaccharide in intestinal organoids from dogs with inflammatory bowel disease and intestinal mast …

DK Sahoo, DC Borcherding, L Chandra, AE Jergens… - Cancers, 2022 - mdpi.com
Simple Summary Lipopolysaccharide (LPS) derived from intestinal bacteria is linked to long-
lasting inflammation that contributes to the development of intestinal cancer. While much …

Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity

JP Mochel, JL Ward, T Blondel, D Kundu… - Scientific Reports, 2024 - nature.com
Cardiovascular-kidney-metabolic health reflects the interactions between metabolic risk
factors, chronic kidney disease, and the cardiovascular system. A growing body of literature …

Canine intestinal organoids as a novel in vitro model of intestinal drug permeability: A proof-of-concept study

DK Sahoo, MN Martinez, K Dao, V Gabriel, C Zdyrski… - Cells, 2023 - mdpi.com
A key component of efforts to identify the biological and drug-specific aspects contributing to
therapeutic failure or unexpected exposure-associated toxicity is the study of drug–intestinal …

Associations of inflammatory cytokines with inflammatory bowel disease: a Mendelian randomization study

Z Song, X Li, J Xie, F Han, N Wang, Y Hou… - Frontiers in …, 2024 - frontiersin.org
Objectives Previous studies have confirmed a link between specific inflammatory cytokines
and inflammatory bowel disease (IBD), but the causal relationship between them is not …

Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

DK Sahoo, D Wong, A Patani, B Paital… - Frontiers in Cellular …, 2024 - frontiersin.org
Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission

PG Doulidis, AI Galler, B Hausmann, D Berry… - Scientific Reports, 2023 - nature.com
The role of the gut microbiome in developing Inflammatory Bowel Disease (IBD) in humans
and dogs has received attention in recent years. Evidence suggests that IBD is associated …

The application of organoids in colorectal diseases

Y Liu, D Wang, Y Luan, B Tao, Q Li, Q Feng… - Frontiers in …, 2024 - frontiersin.org
Intestinal organoids are a three-dimensional cell culture model derived from colon or
pluripotent stem cells. Intestinal organoids constructed in vitro strongly mimic the colon …