[HTML][HTML] Enantioselective synthesis of chiral α,α-dialkyl indoles and related azoles by cobalt-catalyzed hydroalkylation and regioselectivity switch

J Ren, Z Sun, S Zhao, J Huang, Y Wang… - Nature …, 2024 - nature.com
General, catalytic and enantioselective construction of chiral α, α-dialkyl indoles represents
an important yet challenging objective to be developed. Herein we describe a cobalt …

[HTML][HTML] CoH-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes: a rapid approach to chiral five-membered S-and O-heterocycles

L Zhao, F Liu, Y Zhuang, M Shen, J Xue, X Wang… - Chemical …, 2024 - pubs.rsc.org
Saturated heterocycles, which incorporate S and O heteroatoms, serve as fundamental
frameworks in a diverse array of natural products, bioactive compounds, and …

Palladium-Catalyzed Enantioselective Multicomponent Cross-Coupling of Trisubstituted Olefins

W Huang, Y Xi, D Pan, L Fan, K Fang… - Journal of the …, 2024 - ACS Publications
The development of a catalytic method for stereogenic carbon center formation holds
immense significance in organic synthesis. Transition-metal-catalyzed cross-coupling …

Generation of Hydrides or Hydrogen Radicals for Hydrodehalogenation and Deuterodehalogenation of gem-Dihaloalkenes

Z Chang, CY Yao, WJ Feng, YF Zhao, RR Qian… - CCS …, 2024 - chinesechemsoc.org
Terminal monohaloalkenes are common synthetic fragments used in organic synthesis and
are also found in many natural products. Their Z/E stereoisomers are difficult to physically …

Regio-and Enantioselective Hydromethylation of 3-Pyrrolines and Glycals Enabled by Cobalt Catalysis

M Shen, C Niu, X Wang, JB Huang, Z Zhao, SF Ni… - JACS Au, 2024 - ACS Publications
Enantioenriched 3-methylpyrrolidine, with its unique chiral nitrogen-containing core
skeleton, exists widely in various functional molecules, including natural products, bioactive …