In most tissues, the function of Ca2+-and voltage-gated K+ (BK) channels is modified in
response to ethanol concentrations reached in human blood during alcohol intoxication. In …

Abuse-related drug usage is a public health issue. Drosophila melanogaster has been used
as an animal model to study the biological effects of these psychoactive substances in …

Tolerance occurs when, following an initial experience with a substance, more of the
substance is required subsequently to induce identical behavioral effects. Tolerance is not …

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior.
Site (s) and mechanism (s) of ethanol–BK channel interaction are unknown. We …

Sustained or repeated exposure to sedating drugs, such as alcohol, triggers homeostatic
adaptations in the brain that lead to the development of drug tolerance and dependence …

Ethanol is the most common drug of abuse. It exerts its behavioral effects by acting on
widespread neural circuits; however, its impact on glial cells is less understood. We show …

The heavy consumption of ethanol can lead to alcohol use disorders (AUDs) which impact
patients, their families, and societies. Yet the genetic and physiological factors that …

Ethanol has robust effects on presynaptic activity in many neurons, however, it is not yet
clear how this drug acts within this compartment to change neural activity, nor the …

Large conductance calcium-activated (BK) channels are broadly expressed in neurons and
muscle where they modulate cellular activity. Decades of research support an interest in …

Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and
the associated symptoms of withdrawal. These adaptations have been shown to persist for …