The paired-like homeobox-containing gene Rx has a critical role in the eye development of
several vertebrate species including Xenopus, mouse, chicken, medaka, zebrafish and …

Members of the Zic family of zinc finger transcription factors play critical roles in a variety of
developmental processes. They are involved in development of neural tissues and the …

Two major signaling centers have been shown to control patterning of sea urchin embryos.
Canonical Wnt signaling in vegetal blastomeres and Nodal signaling in presumptive oral …

During embryogenesis, multiple developmental processes are integrated through their
precise temporal regulation. Hes1 is a transcriptional repressor that regulates the timing of …

The discovery of undifferentiated, actively proliferating neural stem cells (NSCs) in the
mature brain opened a brand new chapter in the contemporary neuroscience. Adult …

The neural-related genes Sox2, Pax6, Otx2, and Rax have been associated with severe
ocular malformations such as anophthalmia and microphthalmia, but it remains unclear as to …

The brain plays a central role in controlling energy, glucose, and lipid homeostasis, with
specialized neurons within nuclei of the mediobasal hypothalamus, namely the arcuate …

The wall of the ventral third ventricle is composed of two distinct cell populations: tanycytes
and ependymal cells. Tanycytes regulate many aspects of hypothalamic physiology, but little …

Although it is well established that Six3 is a crucial regulator of vertebrate eye and forebrain
development, it is unknown whether this homeodomain protein has a role in the initial …

In vertebrates, the central nervous system (CNS) develops as a highly hierarchical,
patterned organ with a vast diversity of neuronal and glial cell types. The vertebrate retina is …