DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …

Cell cycle checkpoints are regulatory pathways that control the order and timing of cell cycle
transitions and ensure that critical events such as DNA replication and chromosome …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell
cycle. It is shown here that this arrest could be sustained only when p53 was present in the …

p21CIP11WAF1 is a CDK Inhibitor regulated by the tumor suppressor p53 and is
hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic …

Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism
as a component of the replication and repair machinery. This toroidal-shaped protein …

Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in
G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase …

DNA-damaging agents induce a p53-dependent G1 arrest that may be critical for p53-
mediated tumor suppression. It has been suggested that p21WAF1/CIP1, a cdk inhibitory …

G1/S and G2/M cell cycle checkpoints maintain genomic stability in eukaryotes in response
to genotoxic stress. We report here both genetic and functional evidence of a Gadd45 …

The occurrence of DNA double strand breaks induces cell cycle arrest in mortal and
immortal human cells. In normal, mortal fibroblasts this block to proliferation is permanent. It …