Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on formulation approaches

F Molavi, M Barzegar-Jalali, H Hamishehkar - Journal of Controlled …, 2020 - Elsevier
The novel polymeric particulate systems show high potential in their clinical effectiveness.
Nevertheless, many of the drug delivery systems developed in the research laboratories …

Supercritical antisolvent process for pharmaceutical applications: A review

P Franco, I De Marco - Processes, 2020 - mdpi.com
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: an eco-friendly welcome to active pharmaceutical ingredients (APIs)

RK Kankala, PY Xu, BQ Chen, SB Wang… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the success in developing various pharmaceutical formulations, most of the active
pharmaceutical ingredients (APIs)/drugs, according to the Biopharmaceutics Classification …

PLA/PLGA-Based Drug Delivery Systems Produced with Supercritical CO2—A Green Future for Particle Formulation?

G Gangapurwala, A Vollrath, A De San Luis… - Pharmaceutics, 2020 - mdpi.com
Supercritical carbon dioxide (SC-CO2) can serve as solvent, anti-solvent and solute, among
others, in the field of drug delivery applications, eg, for the formulation of polymeric …

Green Processing of Neat Poly (lactic acid) using Carbon Dioxide under elevated pressure for Preparation of Advanced materials: a review (2012–2022)

S Milovanovic, I Lukic, G Horvat, Z Novak, S Frerich… - Polymers, 2023 - mdpi.com
This review provides a concise overview of up-to-date developments in the processing of
neat poly (lactic acid)(PLA), improvement in its properties, and preparation of advanced …

Particle preparation of pharmaceutical compounds using supercritical antisolvent process: current status and future perspectives

R Kumar, AK Thakur, G Kali, KC Pitchaiah… - Drug Delivery and …, 2023 - Springer
The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

Process intensification for the synthesis of ultra-small organic nanoparticles with supercritical CO2 in a microfluidic system

T Jaouhari, F Zhang, T Tassaing… - Chemical Engineering …, 2020 - Elsevier
Submicronization of organic compounds is a challenging requirement for applications in the
imaging and pharmaceutical fields. A new Supercritical AntiSolvent process with …

Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent …

IA Cuadra, A Cabañas, JAR Cheda, M Türk… - The Journal of …, 2020 - Elsevier
Abstract Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and
pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent …

Design and fabrication of hybrid triple-responsive κ-carrageenan-based nanospheres for controlled drug delivery

G Geyik, N Işıklan - International Journal of Biological Macromolecules, 2021 - Elsevier
In the last two decades, the utilization of magnetic nanospheres in intelligent polymeric
structures have received increased attention of researchers in numerous biomedical …

Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods

B Long, V Verma, KM Ryan, L Padrela - The Journal of Supercritical Fluids, 2021 - Elsevier
Posaconazole (PSZ) is a BCS (biopharmaceutical classification system) Class II anti-fungal
drug used to treat infections in immunocompromised patients. The work presented herein …