Bottom-up proteomics: advancements in sample preparation
Liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based proteomics is a
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …
[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
NATs at a glance
Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
Protein N-terminal acetylation: structural basis, mechanism, versatility, and regulation
S Deng, R Marmorstein - Trends in biochemical sciences, 2021 - cell.com
N-terminal acetylation (NTA) is one of the most widespread protein modifications, which
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …
Leguminous plants: inventors of root nodules to accommodate symbiotic bacteria
T Suzaki, E Yoro, M Kawaguchi - International review of cell and molecular …, 2015 - Elsevier
Legumes and a few other plant species can establish a symbiotic relationship with nitrogen-
fixing rhizobia, which enables them to survive in a nitrogen-deficient environment. During …
fixing rhizobia, which enables them to survive in a nitrogen-deficient environment. During …