Exercise intolerance, indicated by dyspnea and fatigue during exertion, is a cardinal
manifestation of heart failure (HF). Cardiopulmonary exercise testing (CPET) precisely …

Chronotropic incompetence (CI) is generally defined as the inability to increase the heart
rate (HR) adequately during exercise to match cardiac output to metabolic demands. In …

Aims The aim of this study was to synthesize the evidence on the effect of heart failure with
reduced ejection fraction (HFrEF) pharmacotherapy on health‐related quality of life …

Heart failure represents a major global cause of morbidity and mortality. Ivabradine is a
selective funny current (If) inhibitor, which acts on the sinoatrial node, resulting in a reduction …

Heart rate is an important contributor in the pathophysiology of both coronary artery disease
(CAD) and heart failure (HF). Ivabradine is an anti-anginal and anti-ischaemic agent, which …

Background: Limited heart rate (HR) rise (HRR) during exercise, known as chronotropic
incompetence (CI), is commonly observed in chronic heart failure (CHF). HRR is closely …

Introduction: Heart failure with reduced ejection fraction (HFrEF) is associated with a worse
outcome. Heart rate (HR) is related to outcome in HFrEF. Ivabradine selectively inhibits If …

Elevated resting heart rate in chronic heart failure (HF) patients has been associated with
higher mortality and poor prognosis. Ivabradine is a new pure bradycardic agent that has …

Objectives To assess the beneficial and harmful effects of adding ivabradine to usual care in
participants with heart failure. Design A systematic review with meta-analysis and trial …

Aims LIVE: LIFE is a multi-centre, open-label, prospective observational cohort study
assessing health-related quality of life (HRQoL) in older patients with chronic heart failure …