It is now widely recognized that a strong correlation exists between cancer and aberrant
hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and …

Simple Summary Tissue factor is a protein that is important for the regulation of blood
coagulation. New research has highlighted the important roles of tissue factor in cancer. This …

For many years, the attention on tissue factor (TF) in human pathophysiology has been
limited to its role as initiator of extrinsic coagulation pathway. Moreover, it was described as …

Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of
the factor VIIa‐TF complex enzyme and plays a primary role in both normal hemostasis and …

Tissue factor (TF) is an integral transmembrane protein associated with the extrinsic
coagulation pathway. TF gene expression is regulated in response to inflammatory …

Background: TF is highly expressed in cancerous and atherosclerotic lesions. Monocyte
recruitment is a hallmark of disease progression in these pathological states. Objective: To …

Background Tissue factor (TF), an initiator of blood coagulation, participates in cancer
progression and metastasis. We recently found that inhibition of MAPK/ERK upregulated …

Background—Alternatively spliced tissue factor (asTF) is a novel isoform of full-length tissue
factor, which exhibits angiogenic activity. Although asTF has been detected in human …

Acute thrombus formation on disrupted atherosclerotic plaques plays a key role during the
onset of acute coronary syndromes. Lesion disruption facilitates the interaction between …

Objective—Tissue factor (TF) triggers arterial thrombosis. TF is also able to initiate cellular
signaling mechanisms leading to angiogenesis. Because high cardiovascular risk …