The immune system is strongly linked to the maintenance of healthy bone. Inflammatory
cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result …

The dynamic nature of the skeleton is achieved by a process called “remodeling” which
involves the co-ordinated actions of osteoclasts, osteoblasts, osteocytes within the bone …

Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining
feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and …

Both lesions of endodontic origin and periodontal diseases involve the host response to
bacteria and the formation of osteolytic lesions. Important for both is the upregulation of …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

In multiple myeloma, an overabundance of monoclonal plasma cells in the bone marrow
induces localized osteolytic lesions that rarely heal due to increased bone resorption and …

Introduction Currently available treatments for osteoarthritis (OA) are restricted to
nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only …

CXCR 4 is a G‐protein‐coupled receptor that mediates recruitment of blood cells toward its
ligand SDF‐1. In cancer, high CXCR 4 expression is frequently associated with tumor …

The development of multiple myeloma (MM) is a complex multi-step process involving both
early and late genetic changes in the tumor cell as well as selective supportive conditions by …

CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation.
A growing body of research suggests CCL2 is progressively overexpressed in tumor beds …