Tobacco smoking causes not only lung cancer but also cancer of the oral and nasal cavities,
oesophagus, larynx, pharynx, pancreas, liver, kidney, stomach, urinary tract and cervix …

Damage to DNA induced by carcinogenic chemicals reflects exposure and is directly related
to tumor formation, whereas modification of protein provides relatively precise dosimetry for …

The demonstration in the mid-1960s and early 1970s that antibodies could be generated
against the normal nucleosides suggested that antibodies to modified nucleosides were …

Environmental, occupational, and recreational exposures to carcinogens contribute to
cancer risk in humans. Cancer formation is a multistage process involving tumor initiation …

DNA adducts associated with tobacco smoking could provide a marker of biologically
effective dose of tobacco carcinogens and improve individual cancer risk prediction. A …

This molecular epidemiologic case-control study of lung cancer incorporated three
complementary biomarkers: the glutathione S-transferase M1 (GSTM1) null genotype, a …

Levels of DNA adducts vary greatly in vivo, attributable to individual differences in enzymatic
bioactivation of benzo (a) pyrene. We developed an assay to measure the levels of DNA …

One in ten tobacco smokers develops bronchogenic carcinoma over a lifetime. The study of
susceptibility of an individual and a population to lung cancer traditionally has been limited …

The presence of carcinogen‐DNA adducts in human tissues is evidence of exposure to
carcinogens and may be an indicator of cancer risk. DNA was isolated from non‐tumorous …

Molecular epidemiology is increasingly being applied in studies of cancer risks derived from
exposure to environmental carcinogens of both endogenous and exogenous origins …