Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Importance Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly
100 000 individuals in the United States and is associated with many acute and chronic …

Despite advances in supportive therapy to prevent complications of sickle cell disease
(SCD), access to care is not universal. Hematopoietic cell transplantation is, to date, the only …

Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow
velocities, regular blood transfusions can effectively prevent primary stroke, but must be …

Background Hydroxyurea is an effective treatment for sickle cell anemia, but few studies
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …

Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Background Missing data are common in medical research, which can lead to a loss in
statistical power and potentially biased results if not handled appropriately. Multiple …

While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

Study objective We provide an updated assessment of trends in sickle cell disease (SCD)–
related mortality, a significant source of mortality in the United States among black persons …