ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …

The human ATP-binding cassette transporter multidrug resistance protein 1 (MRP1),
encoded by ABCC1, was initially identified because of its ability to confer multidrug …

This special issue of Drug Resistance Updates is dedicated to multidrug resistance protein 1
(MDR-1), 35 years after its discovery. While enormous progress has been made and our …

Introduction: Most disseminated cancers remain fatal despite the availability of a variety of
conventional and novel treatments including surgery, chemotherapy, radiotherapy …

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

Cancer, a major public health problem, is one of the world's top leading causes of death.
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …

Abstract Multi-target Tyrosine Kinase Inhibitors (MTKIs) have drawn substantial attention in
tumor therapy. MTKIs could inhibit tumor cell proliferation and induce apoptosis by blocking …

Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …