Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Evolutionary medicine–ie the application of insights from evolution and ecology–has
tremendous untapped potential to spark transformational innovation in biomedicine and …

Cetaceans are a clade of highly specialized aquatic mammals that include the largest
animals that have ever lived. The largest whales can have∼ 1,000× more cells than a …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary …

Sporadic gliomas in companion dogs provide a window on the interaction between
tumorigenic mechanisms and host environment. We compared the molecular profiles of …

As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Cetaceans are the longest-living species of mammals and the largest in the history of the
planet. They have developed mechanisms against diseases such cancer, although the …

Abstract Sir Richard Peto is well known for proposing puzzling paradoxes in cancer biology—
some more well-known than others. In a 1984 piece, Peto proposed that after decades of …

Within primates, the great apes are outliers both in terms of body size and lifespan, since
they include the largest and longest-lived species in the order. Yet, the molecular bases …